Musculoskeletal disorders are the most common cause of severe long-term pain and physical disability worldwide with an estimated cost to society of over $215 billion per year in the USA alone. As the average age of the global population increases, the prevalence of chronic disabling musculoskeletal conditions will continue to grow. Furthermore, musculoskeletal injuries are a major cause of functional impairment in people of all ages.

For this reason, the Guldberg laboratory was established to create strategies and enabling technologies for the functional restoration of damaged or degenerated musculoskeletal tissues with a focus on bone and cartilage. In addition, we use biomechanics and micro-CT imaging to elucidate structure-function relationships in engineered and native tissues.

The Guldberg laboratory has six research focus areas:

Research Areas

MSCs, ADSCs, and AFS cells and their delivery

A critical criterion of tissue engineered constructs is a viable cell source capable of differentiating into a tissue-specific lineage. The availability of cells necessary Read More>>

The skeleton not only provides structure and protection to the body but also participates in metabolic functions and hematopoeisis. Disease pathologies that relate to any of these functions may have associated changes in bone material Read More>>

Effective therapies that restore function following composite tissue injury to bone, muscle, blood vessels, and nerves are an unmet clinical need. In order to investigate novel technologies enabling restoration of limb function following Read More>>

Osteoarthritis (OA) is the most common form of arthritis and the leading cause of chronic disability in the United States (affecting nearly 27 million people). This joint disease impacts the function of multiple tissues, including articular Read More>>

Microcomputed tomography (micro-CT) allows for nondestructive 3D imaging and quantification of microstructural morphology at high resolutions. The Guldberg Lab collaborates with internal and external researchers who seek to utilize micro-CT Read More>>