Brett Klosterhoff

Graduate Research Assistant

Current Research

Bone is regarded as a dynamic “mechanostat,” which constantly remodels its structure in accordance with mechanical demands. In recent years, our group has developed a segmental bone defect model to isolate the role of mechanical signals in skeletal regeneration. While it has been established that ambulatory load transfer enhances successful bone bridging, the precise mechanisms dictating this process are unknown due to limitations in longitudinally assessing the local mechanical environment in vivo. To overcome this, we are leveraging recent advances in implantable microelectromechanical systems (MEMS) technology to monitor mechanical strains on regenerating tissue in vivo. The insights offered by MEMS instrumentation will underpin the development of image-based finite element models which will serve as a parametric design space to address fundamental questions in bone mechanobiology, and to guide translational improvements of novel regenerative strategies through computational simulations.

Additional Info

Woodruff School of Mechanical Engineering

Parker H. Petit Institute for Bioengineering and Bioscience