Jason Wang

Graduate Research Assistant

Current Research

Effects of HIV-1 proteins on skeletal fragility and bone tissue regeneration in the HIV transgenic rat model.

Administration of highly active anti-retroviral therapy (HAART) has extended the life expectancy of individuals infected with HIV and changed the once terminal condition into a manageable chronic disease. However, this population is prematurely challenged with disorders traditionally associated with the natural aging process including cardiovascular disease, renal disease, liver disease, neurocognitive decline, and osteopenia/osteoporosis. The clinical link between HIV infection and concomitant risk for osteoporosis and fragility fractures remains unclear and is further clouded by classical osteoporosis risk factors including vitamin D deficiency, drug use, smoking, and alcohol use. To this end, this project intends to use the HIV-1 transgenic (Tg) rat model to elucidate the influences of HIV protein expression on skeletal fragility. By studying the HIV-1 Tg rat, our findings will contribute to the growing body of knowledge on the effects of HIV infection on skeletal health and perhaps also validate this animal model as a functional surrogate for investigating HIV-associated musculoskeletal disorders.

Additional Info

Woodruff School of Mechanical Engineering

Georgia Institute of Technology

Parker H. Petit Institute of Bioengineering and Biosciences